Breast malignant phyllodes tumor with rare pelvic metastases and long-term overall survival: A case report and literature review

Medicine (Baltimore). 2016 Sep;95(38):e4942. doi: 10.1097/MD.0000000000004942.

Abstract

Background: Malignant phyllodes tumor (PT) is a rare fibro epithelial neoplasm of the breast, which is poor prognosis due to high risk of recurrence and distant metastasis.

Methods: We report a case of malignant PT. It had recurred locally five times, and the sixth relapse was occurred 54 months after first diagnosis, presenting a huge pelvic mass (14 cm × 11 cm) by CT scan. Histopathological examination has demonstrated a metastatic phyllodes tumor. After postoperative chemotherapy treatment, a longer survival has been achieved, which is more than 72 months.

Results: Our case report describes a breast PT with several local recurrences and a rare metastasis (pelvic cavity), but long-term overall survival was achieved after surgery and chemotherapy.

Conclusion: We conclude that trustworthy prognosticators that identify patients with excessive potential of aggressive clinical course should be explored. Moreover, proper treatment could prolong overall survival of metastatic PT patients.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Breast Neoplasms / pathology*
  • Fatal Outcome
  • Female
  • Humans
  • Immunohistochemistry
  • Mastectomy / methods
  • Neoplasm Recurrence, Local / pathology
  • Pelvic Neoplasms / secondary*
  • Pelvic Neoplasms / surgery
  • Pelvis / pathology
  • Phyllodes Tumor / secondary*
  • Positron Emission Tomography Computed Tomography