Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells

Joo-Young Im; Sung-Hoon Yoon; Bo-Kyung Kim; Hyun Seung Ban; Kyoung-Jae Won; Kyung-Sook Chung; Kyeong Eun Jung; Misun Won

doi:10.1016/j.dib.2016.08.066

Data on the transcriptional regulation of DNA damage induced apoptosis suppressor (DDIAS) by ERK5/MEF2B pathway in lung cancer cells

Data Brief. 2016 Sep 6:9:257-61. doi: 10.1016/j.dib.2016.08.066. eCollection 2016 Dec.

Authors

Joo-Young Im¹, Sung-Hoon Yoon², Bo-Kyung Kim¹, Hyun Seung Ban³, Kyoung-Jae Won², Kyung-Sook Chung³, Kyeong Eun Jung⁴, Misun Won²

Affiliations

¹ Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea.
² Personalized Genomic Medicine Research Center, KRIBB, Daejeon 305-806, Korea; Functional Genomics, University of Science and Technology, Daejeon 305-701, Korea.
³ Biomedical Translational Research Center, KRIBB, Daejeon 305-806, Korea.
⁴ ST Pharm. Co., LTD, Sihwa Industrial Complex 1, Kyunggido 429-848, Korea.

Abstract

The data included in this article are associated with the article entitled "DNA-damage-induced apoptosis suppressor (DDIAS) is upregulated via ERK5/MEF2B signaling and promotes β-catenin-mediated invasion" (J.Y. Im, S.H. Yoon, B.K. Kim, H.S. Ban, K.J. Won, K.S. Chung, K.E. Jung, M. Won) [1]. Quantitative RT-PCR data revealed that genetic or pharmacological inhibition of extracellular signal-regulated kinase 5 (ERK5) suppresses DDIAS transcription in response to epidermal growth factor (EGF) in Hela cells. p300 did not interact with myocyte enhancer factor 2B (MEF2B), a downstream target of ERK5 and affect transcription of DDIAS. Moreover, DDIAS transcription is activated by ERK5/MEF2B signaling on EGF exposure in the non-small cell lung cancer cells (NSCLC) NCI-H1703 and NCI-H1299. DDIAS knockdown suppresses lung cancer cell invasion by decreasing β-catenin protein level on EGF exposure.

Keywords: DDIAS; ERK5; Lung cancer; MEF2B.