Current biomarkers of invasive sporadic pituitary adenomas

Xin Zheng; Song Li; Weihua Zhang; Zhenle Zang; Jintao Hu; Hui Yang

doi:10.1016/j.ando.2016.02.004

Current biomarkers of invasive sporadic pituitary adenomas

Ann Endocrinol (Paris). 2016 Dec;77(6):658-667. doi: 10.1016/j.ando.2016.02.004. Epub 2016 Sep 19.

Authors

Xin Zheng¹, Song Li¹, Weihua Zhang², Zhenle Zang¹, Jintao Hu¹, Hui Yang³

Affiliations

¹ Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, 183, Xinqiao Main Street, Shapingba District, Chongqing, China.
² Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.
³ Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, 183, Xinqiao Main Street, Shapingba District, Chongqing, China. Electronic address: yanghui64@hotmail.com.

PMID: 27659267
DOI: 10.1016/j.ando.2016.02.004

Abstract

Though pituitary adenomas (PA) are considered benign, some of them exhibit invasive behaviors such as recurrence and low rate of total surgical resection. Reliable prognostic biomarkers for invasive PA are highly desired; however they remain to be identified. In this review, we summarize the current controversial findings of biomarkers for invasive sporadic PA, and we discuss the possible reasons for the controversies.

Keywords: Adénome hypophysaire; Biomarkers; Biomarqueurs; Invasiveness; Invasivité; Pituitary adenoma.

Publication types

Review

MeSH terms

Adenoma / pathology*
Biomarkers, Tumor* / physiology
Diagnostic Techniques, Endocrine / trends
Humans
Neoplasm Invasiveness
Neoplasm Recurrence, Local / diagnosis
Pituitary Neoplasms / pathology*
Prognosis

Substances

Biomarkers, Tumor