Hypothyroxinemia and Risk for Transient Tachypnea of Newborn

Irena Ulanovsky; Tatiana Smolkin; Shlomo Almashanu; Tanya Mashiach; Imad R Makhoul

doi:10.1016/j.jpeds.2016.08.061

Hypothyroxinemia and Risk for Transient Tachypnea of Newborn

J Pediatr. 2016 Dec:179:266-268.e1. doi: 10.1016/j.jpeds.2016.08.061. Epub 2016 Sep 19.

Authors

Irena Ulanovsky¹, Tatiana Smolkin¹, Shlomo Almashanu², Tanya Mashiach³, Imad R Makhoul⁴

Affiliations

¹ Neonatology Department, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel; Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
² National Newborn Screening Program, Public Health Services, Ministry of Health, Israel.
³ Epidemiology Department, Rambam Health Care Campus, Haifa, Israel.
⁴ Neonatology Department, Ruth Children's Hospital, Rambam Health Care Campus, Haifa, Israel; Epidemiology Department, Rambam Health Care Campus, Haifa, Israel. Electronic address: makhoul@rambam.health.gov.il.

PMID: 27659026
DOI: 10.1016/j.jpeds.2016.08.061

Abstract

Transient tachypnea of newborn is associated with hypothyroxinemia in animals via decreased stimulation of beta-adrenergic receptors and Na-K-ATPase activity. In 26 549 term neonates, serum total thyroxine <14 ug/dL, male sex, and elective cesarean delivery were significantly associated with greater risk for transient tachypnea of newborn.

Keywords: Na-K-ATPase; beta- adrenergic receptors; hypothyroxinemia; newborn infant; transient tachypnea of newborn.

MeSH terms

Female
Humans
Hypothyroidism / complications*
Infant, Newborn
Male
Retrospective Studies
Risk
Thyroxine / blood*
Transient Tachypnea of the Newborn / etiology*

Substances

Thyroxine