Electromagnetic waves carrying orbital angular momentum (OAM) have been used for mode division multiplexing in free-space communication systems to increase both the capacity and the spectral efficiency. In the case of conventional wireless communication links using non-OAM beams, multipath effects caused by beam spreading and reflection from the surrounding objects affect the system performance. This paper presents the results of analysis, simulations, and measurements of multipath effects in a millimetre-wave communication link using OAM multiplexing at 28 GHz. Multipath-induced intra- and inter-channel crosstalk, which are caused by specular reflection from a plane parallel to the propagation path, are analysed and measured. Both the simulation and the experimental results show that an OAM channel with a high OAM number ℓ tends to suffer from both strong intra-channel crosstalk and strong inter-channel crosstalk with other OAM channels. Results of the analysis show that this observation can be explained on the basis of both the properties of OAM beam divergence and the filtering effect at the receiver, which is associated with the spiral wavefront of OAM beams.