Protein Kinases and Parkinson's Disease

Syed Jafar Mehdi; Hector Rosas-Hernandez; Elvis Cuevas; Susan M Lantz; Steven W Barger; Sumit Sarkar; Merle G Paule; Syed F Ali; Syed Z Imam

doi:10.3390/ijms17091585

Protein Kinases and Parkinson's Disease

Int J Mol Sci. 2016 Sep 20;17(9):1585. doi: 10.3390/ijms17091585.

Authors

Syed Jafar Mehdi¹, Hector Rosas-Hernandez², Elvis Cuevas³, Susan M Lantz⁴, Steven W Barger^{5

6}, Sumit Sarkar⁷, Merle G Paule⁸, Syed F Ali⁹, Syed Z Imam^{10

11}

Affiliations

¹ Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. SJMehdi@uams.edu.
² Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Hector.Rosas-Hernandez@fda.hhs.gov.
³ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Elvis-Yane.Cuevas-Martinez@fda.hhs.gov.
⁴ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Susan.Lantz@fda.hhs.gov.
⁵ Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. BargerStevenW@uams.edu.
⁶ Geriatric Research Education and Clinical Center, Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA. BargerStevenW@uams.edu.
⁷ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Sumit.Sarkar@fda.hhs.gov.
⁸ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Merle.Paule@fda.hhs.gov.
⁹ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Syed.Ali@fda.hhs.gov.
¹⁰ Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Syed.Imam@fda.hhs.gov.
¹¹ Division of Neurotoxicology, National Center for Toxicological Research/US Food and Drug Administration, Jefferson, AR 72079, USA. Syed.Imam@fda.hhs.gov.

Abstract

Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson's disease has intensified the search for drugs that can be repurposed or repositioned for such treatment. Typically, the search focuses on drugs that have been approved and are used clinically for other indications. Kinase inhibitors represent a family of popular molecules for the treatment and prevention of various cancers, and have emerged as strong candidates for such repurposing because numerous serine/threonine and tyrosine kinases have been implicated in the pathobiology of Parkinson's disease. This review focuses on various kinase-dependent pathways associated with the expression of Parkinson's disease pathology, and evaluates how inhibitors of these pathways might play a major role as effective therapeutic molecules.

Keywords: Parkinson’s disease; dopamine; kinase inhibitors; serine/threonine kinase; tyrosine kinase.

Publication types

Review