NBR2 (neighbor of BRCA1 gene 2) is a non-protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate-activated protein kinase (AMPK) activation.
Keywords: AMPK; BRCA1; NBR2; energy stress response; lncRNA; tumor suppression.