Primary focal segmental glomerulosclerosis: miRNAs and targeted therapies

Abstract

Background: Primary focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome.

Aims: The pathogenic steps leading to primary FSGS are still obscure, although evidence suggests that circulatory factor(s) are involved in the onset of disease.

Results: Recent technical advances allow the analysis of miRNA expression in tissues and body fluids, leading to reports of miRNAs involved in the molecular mechanisms of FSGS-aetiopathogenesis. Moreover, investigations have also highlighted miRNAs that might serve as biomarkers for primary FSGS.

Discussion/conclusions: The aim of this review was to summarize reports showing a direct relation between miRNAs and primary FSGS. In addition, the impact of identified miRNAs on treatment response, prediction of the disease onset as well as the regulation in different disease activities is summarized.

Keywords: FSGS; micro-RNA; podocytes.