Objective: To assess the impact of metabolic syndrome(MS) on Framingham risk score(FRS) in patients with type 2 diabetes mellitus (T2DM).
Methods: The anthropometric and biochemical data of 1708 patients with T2DM admitted in hospital from May 2008 to April 2013 were retrospectively analyzed, including 902 males and 806 females with a mean age of 57.1±11.8 years (20-79 years). Diagnosis of MS was made according to the criteria of the Adult Treatment Panel Ⅲ Criteria modified for Asians.
Results: Compared to non-MS/T2DM patients, MS/T2DM patients had higher waist circumference, body weight, body mass index, systolic and diastolic blood pressure, fasting C peptide, total cholesterol, triglyceride, and LDL-C (P<0.05), while lower HDL-C (P<0.01). Both FRS [13.0(10.0, 15.0) vs 11.0(9.0, 13.0) in male,15.0(12.0, 18.0) vs 12.0(6.0, 14.8) in female,P<0.01)] and 10-year cardiovascular risk [12.0%(6.0%, 20.0%) vs 8.0%(5.0%,12.0%) in male,3.0%(1.0%, 6.0%) vs 1.0%(0.0%, 2.8%) in female,P<0.01] were higher in MS/T2DM patients than those in non-MS/T2DM patients.Both FRS and 10-year cardiovascular risk were increased with the components of MS.
Conclusion: T2DM patients with MS have more cardiovascular risk factors, higher FRS and 10-year cardiovascular risk.
目的: 采用Framingham心血管危险评分（FRS）探讨2型糖尿病患者合并代谢综合征对10年心血管疾病风险的影响。
方法: 入选1708例于2008年5月至2013年4月在浙江大学医学院附属第二医院住院治疗的2型糖尿病患者，测定人体形态学和生化指标。采用ATPⅢ 2005亚洲标准诊断代谢综合征，按不同性别分为未合并代谢综合征组和合并代谢综合征组。
结果: 男女性2型糖尿病合并代谢综合征组腰围、体质量、体质指数、收缩压、舒张压、空腹c肽、总胆固醇、甘油三酯和低密度脂蛋白胆固醇均高于未合并代谢综合征组（均 P < 0.05），高密度脂蛋白胆固醇低于未合并代谢综合征组（ P < 0.01）。合并代谢综合征组FRS男性[13.0（10.0，15.0）与11.0（9.0，13.0）]、女性[15.0（12.0，18.0）与12.0（6.0，14.8）]和10年心血管风险男性[12.0%（6.0%，20.0%）与8%（5.0%，12.0%）]、女性[3.0%（1.0%，6.0%）与1.0%（0.0%，2.8%）]均高于未合并代谢综合征组（均 P < 0.01）。FRS和10年心血管风险随代谢综合征组分增加而增加。
结论: 2型糖尿病患者合并代谢综合征心血管危险因素增加，进一步增加FRS和10年心血管疾病风险。