Morphoproteomics Identifies Etiopathogenetic Correlates of HHV-8-Associated Kaposi's Sarcoma and Provides Pathways with Therapeutic Options: A Case Study

Suhair Al Salihi; Jamie Buryanek; Adan A Rios; Robert E Brown

Morphoproteomics Identifies Etiopathogenetic Correlates of HHV-8-Associated Kaposi's Sarcoma and Provides Pathways with Therapeutic Options: A Case Study

Ann Clin Lab Sci. 2016 Sep;46(5):537-43.

Authors

Suhair Al Salihi¹, Jamie Buryanek², Adan A Rios³, Robert E Brown²

Affiliations

¹ Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA Suhair.A.alsalihi@uth.tmc.edu.
² Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.
³ Department of Internal Medicine, The University of Texas Health Science Center at Houston-McGovern Medical School, Houston, TX, USA.

PMID: 27650622

Abstract

A morphoproteomic analysis was performed to identify the proteins and corresponding molecular pathways activated for a case of non-HIV Kaposi's sarcoma. This analysis provides insight into the biology of the tumor and identifies etiopathogenetic correlates of HHV-8-Associated Kaposi's sarcoma that are useful in formulating therapeutic alternatives.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Herpesvirus 8, Human / physiology*
Humans
Male
Models, Biological
Neoplasm Proteins / metabolism
Proteomics / methods*
Sarcoma, Kaposi / metabolism*
Sarcoma, Kaposi / pathology
Sarcoma, Kaposi / therapy*
Sarcoma, Kaposi / virology

Substances

Neoplasm Proteins