Outbreak of OXA-48-Producing Klebsiella pneumoniae Involving a Sequence Type 101 Clone in Batna University Hospital, Algeria

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7494-7497. doi: 10.1128/AAC.00525-16. Print 2016 Dec.

Abstract

Seven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the blaOXA-48, blaCTX-M-15, blaSHV-1, and blaTEM-1D genes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The blaOXA-48 gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital.

MeSH terms

  • Algeria / epidemiology
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / drug therapy
  • Bacteremia / epidemiology*
  • Bacteremia / microbiology
  • Clone Cells
  • Conjugation, Genetic
  • Disease Outbreaks*
  • Ertapenem
  • Gene Expression
  • Hospitals, University
  • Humans
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / epidemiology*
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / classification
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / genetics*
  • Klebsiella pneumoniae / isolation & purification
  • Nephritis / drug therapy
  • Nephritis / epidemiology*
  • Nephritis / microbiology
  • Phylogeny
  • Plasmids / chemistry
  • Plasmids / metabolism
  • beta-Lactam Resistance / genetics
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-Lactamases
  • oxacillinase
  • Ertapenem