Abstract
Seven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the blaOXA-48, blaCTX-M-15, blaSHV-1, and blaTEM-1D genes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The blaOXA-48 gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital.
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MeSH terms
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Algeria / epidemiology
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Anti-Bacterial Agents / pharmacology
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Bacteremia / drug therapy
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Bacteremia / epidemiology*
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Bacteremia / microbiology
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Clone Cells
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Conjugation, Genetic
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Disease Outbreaks*
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Ertapenem
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Gene Expression
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Hospitals, University
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Humans
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Klebsiella Infections / drug therapy
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Klebsiella Infections / epidemiology*
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Klebsiella Infections / microbiology
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Klebsiella pneumoniae / classification
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Klebsiella pneumoniae / drug effects
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Klebsiella pneumoniae / genetics*
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Klebsiella pneumoniae / isolation & purification
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Nephritis / drug therapy
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Nephritis / epidemiology*
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Nephritis / microbiology
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Phylogeny
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Plasmids / chemistry
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Plasmids / metabolism
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beta-Lactam Resistance / genetics
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beta-Lactamases / genetics*
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beta-Lactamases / metabolism
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beta-Lactams / pharmacology
Substances
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Anti-Bacterial Agents
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beta-Lactams
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beta-Lactamases
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oxacillinase
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Ertapenem