Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children

Pediatr Infect Dis J. 2016 Dec;35(12):1336-1338. doi: 10.1097/INF.0000000000001328.

Abstract

We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chemokine CXCL10 / analysis*
  • Chemokine CXCL10 / immunology
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Interferon-gamma / analysis*
  • Interferon-gamma / immunology
  • Interferon-gamma Release Tests / methods*
  • Male
  • Mycobacterium tuberculosis / immunology*
  • Prospective Studies
  • Tuberculin Test
  • Tuberculosis / diagnosis*
  • Tuberculosis / immunology

Substances

  • CXCL10 protein, human
  • Chemokine CXCL10
  • Interferon-gamma