Recent Advances in Assessing Immunogenicity of Therapeutic Proteins: Impact on Biotherapeutic Development

J Immunol Res. 2016:2016:8141269. doi: 10.1155/2016/8141269. Epub 2016 Aug 23.

Authors

Yanmei Lu¹, Leslie A Khawli², Shobha Purushothama³, Frank-Peter Theil³, Michael A Partridge⁴

Affiliations

¹ Departments of Biochemical & Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
² Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
³ UCB Pharma, Slough, Berkshire SL1 14EN, UK.
⁴ Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

No abstract available

Publication types

Editorial
Introductory Journal Article

MeSH terms

Animals
Antibodies, Monoclonal / adverse effects
Antibodies, Monoclonal / immunology
Antibodies, Monoclonal / therapeutic use
Biological Products / adverse effects
Biological Products / immunology*
Biological Products / therapeutic use*
Biological Therapy / adverse effects
Biological Therapy / methods
Drug-Related Side Effects and Adverse Reactions
Humans
Isoantibodies / blood
Isoantibodies / immunology
Proteins / adverse effects
Proteins / immunology*
Proteins / therapeutic use*
Treatment Outcome

Substances

Antibodies, Monoclonal
Biological Products
Isoantibodies
Proteins