Abstract
Acute kidney injury (AKI) is manifested by inflammation, and an early feature in the pathogenesis is the accumulation of immune cells in the kidney. Natural killer T (NKT) cells, a peculiar T cells subtype, serve as a bridge between innate and adaptive immunity. Due to the difference between type I and type II subsets, NKT cells were supposed to play a dual role in IR-related tissue injury. Furthermore, membrane receptors and clinical immunosuppressive agents remain involved in the modulation of NKT cell function. Therefore, regulation of the amount and viability of NKT cells becomes a potential strategy in amelioration of AKI. This review will highlight the recent insights gained into the role and mechanisms of NKT cells in AKI.
Keywords:
NKT cells; acute kidney injury; angel or evil; immunity; inflammation; pathogenesis.
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MeSH terms
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Acute Kidney Injury / drug therapy
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Acute Kidney Injury / genetics
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Acute Kidney Injury / immunology*
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Acute Kidney Injury / pathology
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Adaptive Immunity / drug effects
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Animals
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Anti-Inflammatory Agents / pharmacology
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Antigens, CD1d / genetics
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Antigens, CD1d / immunology*
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Cell Lineage / drug effects
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Cell Lineage / immunology
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Disease Models, Animal
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Gene Expression Regulation
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Humans
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Immunity, Innate / drug effects
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Interferon-gamma / genetics
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Interferon-gamma / immunology*
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Interleukins / genetics
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Interleukins / immunology*
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Natural Killer T-Cells / classification
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Natural Killer T-Cells / drug effects
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Natural Killer T-Cells / immunology*
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Natural Killer T-Cells / pathology
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Receptors, Antigen, T-Cell / classification
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Receptors, Antigen, T-Cell / genetics
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction
Substances
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Anti-Inflammatory Agents
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Antigens, CD1d
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Interleukins
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Receptors, Antigen, T-Cell
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Interferon-gamma