Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan

Arshad Javaid; Mazhar Ali Khan; Mir Azam Khan; Sumaira Mehreen; Anila Basit; Raza Ali Khan; Muhammad Ihtesham; Irfan Ullah; Afsar Khan; Ubaid Ullah

doi:10.1016/j.apjtm.2016.07.017

Screening outcomes of household contacts of multidrug-resistant tuberculosis patients in Peshawar, Pakistan

Asian Pac J Trop Med. 2016 Sep;9(9):909-912. doi: 10.1016/j.apjtm.2016.07.017. Epub 2016 Jul 26.

Authors

Affiliations

¹ Post Graduate Medical Institute, Lady Reading Hospital, Peshawar, Pakistan; Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital, Peshawar, Pakistan.
² Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital, Peshawar, Pakistan. Electronic address: mali_smile2005@yahoo.com.
³ Peshawar Medical College, Peshawar, Pakistan.
⁴ Programmatic Management of Drug Resistant TB Unit, Lady Reading Hospital, Peshawar, Pakistan.
⁵ Kohat University of Science and Technology, Kohat, Pakistan.

PMID: 27633308
DOI: 10.1016/j.apjtm.2016.07.017

Abstract

Objective: To assess the profile of TB/multidrug-resistant TB (MDR-TB) among household contacts of MDR-TB patients.

Methods: Close contacts of MDR-TB patients were traced in the cross-sectional study. Different clinical, radiological and bacteriological were performed to rule out the evidence of TB/MDR-TB.

Results: Between January 2012 and December 2012, a total of 200 index MDR-TB patients were initiated on MDR-TB treatment, out of which home visit and contacts screening were conducted for 154 index cases. Of 610 contacts who could be studied, 41 (17.4%) were diagnosed with MDR-TB and 10 (4.2%) had TB. The most common symptoms observed were cough, chest pain and fever.

Conclusions: The high incidence of MDR-TB among close contacts emphasize the need for effective contact screening programme of index MDR-TB cases in order to cut the chain of transmission of this disease.

Keywords: Household contacts; MDR-TB; Pakistan; Peshawar; Tuberculosis.