Zymomonas mobilis as a model system for production of biofuels and biochemicals

Shihui Yang; Qiang Fei; Yaoping Zhang; Lydia M Contreras; Sagar M Utturkar; Steven D Brown; Michael E Himmel; Min Zhang

doi:10.1111/1751-7915.12408

Zymomonas mobilis as a model system for production of biofuels and biochemicals

Microb Biotechnol. 2016 Nov;9(6):699-717. doi: 10.1111/1751-7915.12408. Epub 2016 Sep 15.

Authors

Shihui Yang^{1

2}, Qiang Fei^{3

4}, Yaoping Zhang⁵, Lydia M Contreras⁶, Sagar M Utturkar⁷, Steven D Brown^{7

8

9}, Michael E Himmel¹⁰, Min Zhang¹¹

Affiliations

¹ National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA. shhyoung@hotmail.com.
² Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei Key Laboratory of Industrial Biotechnology, College of Life Sciences, Hubei University, Wuhan, 430062, China. shhyoung@hotmail.com.
³ National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.
⁴ School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
⁵ Great Lakes Bioenergy Research Center, Wisconsin Energy Institute, University of Wisconsin, Madison, WI, 53726, USA.
⁶ McKetta Department of Chemical Engineering, University of Texas, Austin, TX, 78712, USA.
⁷ Graduate School of Genome Science and Technology, University of Tennessee, Knoxville, TN, 37919, USA.
⁸ BioEnergy Science Center, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
⁹ Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
¹⁰ Biosciences Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA.
¹¹ National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, 80401, USA. min.zhang@nrel.gov.

Abstract

Zymomonas mobilis is a natural ethanologen with many desirable industrial biocatalyst characteristics. In this review, we will discuss work to develop Z. mobilis as a model system for biofuel production from the perspectives of substrate utilization, development for industrial robustness, potential product spectrum, strain evaluation and fermentation strategies. This review also encompasses perspectives related to classical genetic tools and emerging technologies in this context.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biofuels*
Biological Products / metabolism*
Biotechnology / methods
Fermentation
Metabolic Engineering / methods
Zymomonas / genetics
Zymomonas / metabolism*

Substances

Biofuels
Biological Products