Abstract
Seven novel spiromeroterpenoids, asnovolins A-G (1-7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A-G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.
MeSH terms
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Aspergillus / chemistry
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Drug Screening Assays, Antitumor
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Fibronectins
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Spiro Compounds / chemistry
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Spiro Compounds / isolation & purification*
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Spiro Compounds / pharmacology*
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology*
Substances
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FN1 protein, human
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Fibronectins
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Spiro Compounds
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Terpenes
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asnovolin E
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novofumigatonin