Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation

Joanna J Phillips; Henry Gong; Katharine Chen; Nancy M Joseph; Jessica van Ziffle; Lee-Way Jin; Boris C Bastian; Andrew W Bollen; Arie Perry; Theodore Nicolaides; David A Solomon; Joseph T Shieh

doi:10.1007/s00401-016-1616-3

Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation

Acta Neuropathol. 2016 Nov;132(5):757-760. doi: 10.1007/s00401-016-1616-3. Epub 2016 Sep 13.

Authors

Joanna J Phillips^{1

2

3}, Henry Gong⁴, Katharine Chen⁴, Nancy M Joseph^{5

6}, Jessica van Ziffle⁵, Lee-Way Jin^{7

8}, Boris C Bastian^{9

5}, Andrew W Bollen^{10

9}, Arie Perry^{4

10

9}, Theodore Nicolaides^{4

11}, David A Solomon^{10

9

5}, Joseph T Shieh^{12

13}

Affiliations

¹ Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Building, HD492B, San Francisco, CA, 94143, USA. joanna.phillips@ucsf.edu.
² Division of Neuropathology, Department of Pathology, University of California San Francisco, San Francisco, CA, USA. joanna.phillips@ucsf.edu.
³ Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA. joanna.phillips@ucsf.edu.
⁴ Department of Neurological Surgery, University of California San Francisco, Helen Diller Family Cancer Building, HD492B, San Francisco, CA, 94143, USA.
⁵ Clinical Cancer Genomics Laboratory, University of California San Francisco, San Francisco, CA, USA.
⁶ Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
⁷ Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, CA, USA.
⁸ M.I.N.D. (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis Medical Center, Sacramento, CA, USA.
⁹ Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.
¹⁰ Division of Neuropathology, Department of Pathology, University of California San Francisco, San Francisco, CA, USA.
¹¹ Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
¹² Division of Medical Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
¹³ Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA.

No abstract available

Publication types

Case Reports
Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Astrocytoma / genetics*
Astrocytoma / pathology
Brain Neoplasms / genetics*
Brain Neoplasms / pathology
DNA Helicases / genetics
Exons / genetics
Female
Glutamic Acid / genetics
Humans
Male
Mitogen-Activated Protein Kinase Kinases / metabolism
Mutation / genetics*
Nuclear Proteins / genetics
Nuclear Respiratory Factor 1 / genetics*
Oncogene Fusion / genetics*
Proto-Oncogene Proteins B-raf / genetics*
Signal Transduction / genetics
Time Factors
Transcription Factors / genetics
Tripartite Motif-Containing Protein 28 / genetics
Tumor Suppressor Protein p53 / genetics
Valine / genetics
World Health Organization
Young Adult
raf Kinases / genetics*

Substances

NRF1 protein, human
Nuclear Proteins
Nuclear Respiratory Factor 1
TP53 protein, human
Transcription Factors
Tumor Suppressor Protein p53
Glutamic Acid
TRIM28 protein, human
Tripartite Motif-Containing Protein 28
BRAF protein, human
Proto-Oncogene Proteins B-raf
raf Kinases
Mitogen-Activated Protein Kinase Kinases
SMARCA4 protein, human
DNA Helicases
Valine

Publication types

MeSH terms

Substances

Grants and funding