Developing a unifying theory for the functional architecture of endothermic thermoregulation has been proven to be a challenging endeavor. Three papers published in this issue of Temperature take a closer look at this problem and add interesting views to our knowledge about the way that endothermic thermoregulation works.
Keywords: calorimetry; comparator; heat regulation; homeostasis; nitrous oxide; null zone; set point; thermoeffector responses; thermoregulatory threshold.