Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

Ta-Yuan Whuang; Wen-Cheng Tsai; Nan-Fu Chen; Zhi-Cheng Chen; Kuan-Hao Tsui; Zhi-Hong Wen; Yin-Di Su; Yu-Chia Chang; Yu-Hsin Chen; Mei-Chin Lu; Lee-Shing Fang; Jih-Jung Chen; Tung-Ying Wu; Yang-Chang Wu; Ping-Jyun Sung

doi:10.1016/j.bmcl.2016.09.007

Columnaristerol A, a novel 19-norsterol from the Formosan octocoral Nephthea columnaris

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4966-4969. doi: 10.1016/j.bmcl.2016.09.007. Epub 2016 Sep 4.

Authors

Ta-Yuan Whuang¹, Wen-Cheng Tsai², Nan-Fu Chen³, Zhi-Cheng Chen⁴, Kuan-Hao Tsui⁵, Zhi-Hong Wen⁶, Yin-Di Su⁷, Yu-Chia Chang⁸, Yu-Hsin Chen⁹, Mei-Chin Lu¹, Lee-Shing Fang¹⁰, Jih-Jung Chen¹¹, Tung-Ying Wu¹², Yang-Chang Wu¹³, Ping-Jyun Sung¹⁴

Affiliations

¹ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
² Medicine Department, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 833, Taiwan.
³ Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802, Taiwan; Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
⁴ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
⁵ Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan; Department of Obstetrics and Gynecology and Institute of Clinical Medicine, National Yang-Ming University, Taipei 112, Taiwan; Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
⁶ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
⁷ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
⁸ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Doctoral Degree Program of Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan.
⁹ National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan.
¹⁰ Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan.
¹¹ Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan.
¹² Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan.
¹³ Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan; Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: yachwu@mail.cmu.edu.tw.
¹⁴ Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan; National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan. Electronic address: pjsung@nmmba.gov.tw.

PMID: 27623548
DOI: 10.1016/j.bmcl.2016.09.007

Abstract

Columnaristerol A (1), a rare natural 19-norsterol possessing a 10β-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines.

Keywords: 19-Norsterol; Columnaristerol; Cytotoxicity; Nephthea columnaris.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / metabolism*
Carbon-13 Magnetic Resonance Spectroscopy
Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Norsteroids / chemistry*
Norsteroids / pharmacology*
Proton Magnetic Resonance Spectroscopy
Sterols / chemistry*
Sterols / pharmacology*
Structure-Activity Relationship
Taiwan

Substances

Norsteroids
Sterols
columnaristerol A