Sleep-disordered breathing and disorders of glucose metabolism

Abstract

Aims: The authors identified the risk of disorders of glucose metabolism (DGM) for sleep-disordered breathing (SDB).

Methods: We conducted a cross-sectional study in 536 men aged 33-84 years. Patients with diabetes medication were excluded for the analysis and DGM were diagnosed by fasting plasma glucose≥100mg/dl and/or 2h plasma glucose ≥140mg/dl.

Results: The prevalence of DGM in subjects with and without severe SDB, which was judged by an apnea-hypopnea index (AHI) of 30, were 64.9% and 53.3%, which showed no significant difference. The adjusted odds ratios (ORs) (95% confidence intervals [CIs]) of the logarithmic-transformed AHI and that of C-reactive protein for DGM were 1.3 (0.87-2.0) and 2.3 (1.5-3.6), respectively. When the subjects were categorized by the severity of SDB, the ORs (95% CIs) of subjects with mild, moderate and severe SDB against subjects without SDB were 2.9 (1.8-4.6), 1.2 (0.72-2.1) and 1.5 (0.8-3.0), respectively.

Conclusion: A significant association was observed between mild SDB and the presence of DGM in male subjects of this study.

Keywords: Apnea-hypopnea index; Glucose metabolism; Risk assessment; Sleep disordered breathing.