Positional and Curvature Difference of Lamina Cribrosa According to the Baseline Intraocular Pressure in Primary Open-Angle Glaucoma: A Swept-Source Optical Coherence Tomography (SS-OCT) Study

Yong Woo Kim; Jin Wook Jeoung; Michael J A Girard; Jean Martial Mari; Ki Ho Park

doi:10.1371/journal.pone.0162182

Positional and Curvature Difference of Lamina Cribrosa According to the Baseline Intraocular Pressure in Primary Open-Angle Glaucoma: A Swept-Source Optical Coherence Tomography (SS-OCT) Study

PLoS One. 2016 Sep 9;11(9):e0162182. doi: 10.1371/journal.pone.0162182. eCollection 2016.

Authors

Yong Woo Kim¹, Jin Wook Jeoung², Michael J A Girard^{3

4}, Jean Martial Mari⁵, Ki Ho Park²

Affiliations

¹ Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.
² Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
³ Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
⁴ Singapore Eye Research Institute, Singapore, Singapore.
⁵ University of French Polynesia, Tahiti, French Polynesia.

Abstract

Purpose: To investigate the variation of lamina cribrosa (LC) structure based on the baseline intraocular pressure (IOP) in eyes with primary open-angle glaucoma (POAG) and healthy individuals using swept-source optical coherence tomography.

Methods: A total of 108 eyes with POAG and 61 healthy eyes were recruited. Based on the baseline IOP, the POAG eyes were divided into higher-baseline IOP (HTG; baseline IOP > 21 mmHg, n = 38 eyes) and lower-baseline IOP (NTG; baseline IOP ≤ 21 mmHg, n = 70 eyes). The anterior laminar insertion depth (ALID), mean LC depth (mLCD), and the LC curvature index (mLCD-ALID) were measured, and compared among the three groups. The regional variation of LC structure was evaluated by vertical-horizontal ALID difference.

Results: The mLCD and LC curvature index were greatest in HTG eyes (520.3 ± 123.0 and 80.9 ± 30.7 μm), followed by NTG (463.2 ± 110.5 and 64.5 ± 30.7 μm) and healthy eyes (382.9 ± 107.6 and 47.6 ± 25.7 μm, all P < 0.001). However, there were no significant difference in ALID between HTG and NTG eyes. The vertical-horizontal ALID difference was larger in NTG eyes (72.8 ± 56.2 μm) than in HTG (32.7 ± 61.4 μm, P = 0.004) and healthy eyes (25.5 ± 34.8 μm, P < 0.001).

Conclusions: Lamina cribrosa position and curvature differed in POAG eyes with low and high IOP. This would support the theory that IOP induced biomechanical effects on the optic play a role on glaucoma.

MeSH terms

Adult
Female
Glaucoma, Open-Angle / diagnosis*
Glaucoma, Open-Angle / physiopathology*
Humans
Intraocular Pressure / physiology
Male
Middle Aged
Optic Disk / physiopathology
Tomography, Optical Coherence*
Visual Acuity / physiology
Visual Fields / physiology

Grants and funding

This work was supported by a grant of NUS Young Investigator Award (NUSYIA_FY13_P03, R-397-000-174-133). The funding organizations had no role in the design or conduct of this research.