Gold nanoparticles synthesized using Panax ginseng leaves suppress inflammatory - mediators production via blockade of NF-κB activation in macrophages

Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):270-276. doi: 10.1080/21691401.2016.1228661. Epub 2016 Sep 9.

Abstract

In the present study, we report that Gold nanoparticles (AuNPs) synthesized using the leaf extract of Panax ginseng Meyer (P.g AuNPs) exert anti-inflammatory effects through inhibition of downstream NF-κB activation in macrophages. We found that P.g AuNPs reduced the expression of the inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PEG2), interleukin (IL)-6, tumor necrosis factor-α (TNF-α) was attenuated by P.g AuNPs. Furthermore, P.g AuNPs suppressed lipopolysaccharide (LPS)-induced activation of NF-κB signaling pathway via p38 mitogen-activated protein kinase (MAPK) in RAW 264.7 cells. Taken together, our results suggest that P.g AuNPs can be utilized as a novel therapeutic agent for the prevention and cure of inflammation.

Keywords: Inflammation; NF-κB; P. ginseng; gold nanoparticles; green synthesis.

MeSH terms

  • Animals
  • Cell Line
  • Gold* / chemistry
  • Gold* / pharmacology
  • Inflammation Mediators / metabolism*
  • MAP Kinase Signaling System / drug effects
  • Macrophages / metabolism*
  • Metal Nanoparticles / chemistry*
  • Mice
  • NF-kappa B / metabolism*
  • Panax / chemistry*
  • p38 Mitogen-Activated Protein Kinases / metabolism

Substances

  • Inflammation Mediators
  • NF-kappa B
  • Gold
  • p38 Mitogen-Activated Protein Kinases