[Fibrates therapy: Rational use fenofibrate 2016. Executive summary]

Clin Investig Arterioscler. 2016 Nov-Dec;28(6):295-301. doi: 10.1016/j.arteri.2016.06.001. Epub 2016 Sep 5.
[Article in Spanish]

Abstract

To control lipid factors risk, beyond proper management of LDL cholesterol according to individual risk, detection and treatment of atherogenic dyslipidemia and abnormal levels of triglycerides or HDL cholesterol it should be considered for address a global cardiovascular protection, both in primary and secondary prevention. In this sense, these recommendations collect data on efficacy and safety about the combination statin with fibrates, often necessary for total control of dyslipidemia, particularly in patients with metabolic disorders such as diabetes mellitus, metabolic syndrome or visceral obesity. Reference to control and monitoring of treatment is also done, as well as benefits of fenofibrate not linked directly to their lipid-lowering effect.

Keywords: Atherogenic dyslipidemia; Cardiovascular risk; Dislipidemia aterogénica; Fenofibrate; Fenofibrato; Fibrates; Fibratos; Riesgo cardiovascular; Triglicéridos; Triglycerides.

MeSH terms

  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control*
  • Drug Therapy, Combination
  • Dyslipidemias / complications
  • Dyslipidemias / drug therapy
  • Fenofibrate / administration & dosage
  • Fenofibrate / adverse effects
  • Fenofibrate / therapeutic use*
  • Fibric Acids / administration & dosage
  • Fibric Acids / adverse effects
  • Fibric Acids / therapeutic use
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypolipidemic Agents / administration & dosage
  • Hypolipidemic Agents / adverse effects
  • Hypolipidemic Agents / therapeutic use*
  • Lipids / blood
  • Metabolic Diseases / complications
  • Metabolic Diseases / drug therapy
  • Risk Factors

Substances

  • Fibric Acids
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents
  • Lipids
  • Fenofibrate