Anti-hsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis: (ir)Relevance to disease pathogenesis

Georgios Efthymiou; Efthymios Dardiotis; Christos Liaskos; Emmanouela Marou; Vana Tsimourtou; Thomas Scheper; Wolfgang Meyer; Alexandros Daponte; Lazaros I Sakkas; Georgios Hadjigeorgiou; Dimitrios P Bogdanos

doi:10.1016/j.jneuroim.2016.06.009

Anti-hsp60 antibody responses based on Helicobacter pylori in patients with multiple sclerosis: (ir)Relevance to disease pathogenesis

J Neuroimmunol. 2016 Sep 15:298:19-23. doi: 10.1016/j.jneuroim.2016.06.009. Epub 2016 Jun 23.

Affiliations

¹ Cellular Immunotherapy & Molecular Immunodiagnostics, Biomedical Section, Centre for Research and Technology-Hellas (CERTH), Institute for Research and Technology-Thessaly (IRETETH), 41222 Larissa, Greece; Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece; Department of Rheumatology, University General Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 41110 Larissa, Greece.
² Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece.
³ Cellular Immunotherapy & Molecular Immunodiagnostics, Biomedical Section, Centre for Research and Technology-Hellas (CERTH), Institute for Research and Technology-Thessaly (IRETETH), 41222 Larissa, Greece; Department of Rheumatology, University General Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 41110 Larissa, Greece.
⁴ Institute of Immunology, EUROIMMUN, 23560 Lubeck, Germany.
⁵ Department of Obstetrics and Gyneocology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 40500 Larissa, Greece.
⁶ Department of Rheumatology, University General Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 41110 Larissa, Greece.
⁷ Cellular Immunotherapy & Molecular Immunodiagnostics, Biomedical Section, Centre for Research and Technology-Hellas (CERTH), Institute for Research and Technology-Thessaly (IRETETH), 41222 Larissa, Greece; Department of Rheumatology, University General Hospital, Faculty of Medicine, School of Health Sciences, University of Thessaly, Viopolis, 41110 Larissa, Greece. Electronic address: bogdanos@med.uth.gr.

PMID: 27609271
DOI: 10.1016/j.jneuroim.2016.06.009

Abstract

In view of published data suggesting that Helicobacter pylori (Hp) is a trigger of multiple sclerosis (MS), we assessed anti-heat shock protein 60 (hsp60)Hp antibody reactivity in 129 MS patients and 48 demograpically-matched healthy controls (HCs). Anti-Hp antibodies by ELISA were more elevated in MS than HCs but did not differ between different MS phenotypes. All anti-Hp-positive MS sera, irrespectively of their clinical phenotype, were anti-anti-hsp60 positive. Anti-hsp60 Hp seropositivity correlated with age at disease onset. In conclusion, anti-hsp60 Hp antibodies are present in all anti-Hp positive MS patients, and their relevance to disease pathogenesis is questionable.

Keywords: Antibody; Autoimmunity; Heat shock protein; Molecular mimicry.

MeSH terms

Adult
Age Factors
Antibodies, Bacterial / blood*
Bacterial Proteins / immunology*
Chaperonin 60 / immunology*
Female
Helicobacter Infections / complications*
Helicobacter pylori / immunology
Helicobacter pylori / pathogenicity*
Humans
Male
Middle Aged
Multiple Sclerosis* / blood
Multiple Sclerosis* / etiology
Multiple Sclerosis* / immunology

Substances

Antibodies, Bacterial
Bacterial Proteins
Chaperonin 60