Novel 9, 10-dihydrophenanthrene derivatives from Eria bambusifolia with cytotoxicity aganist human cancer cells in vitro

Chin J Nat Med. 2016 Aug;14(8):621-5. doi: 10.1016/S1875-5364(16)30073-5.

Abstract

The present study was designed to identify bioactive compounds similar to those isolated from Dendrobium genus from its relative specie Eria bambusifolia. Compounds 1-10 were isolated and purified using silica gel, MCI CHP-20 gel, Sephadex LH-20, and Lichroprep RP-18 chromatography methods. Their structures were elucidated by means of extensive spectroscopic analyses. The cytotoxicity of these compounds against five human cancer cell lines was tested. Erathrins A and B (1 and 2) were new compounds, and compound 1 represented a novel carbon framework having a phenanthrene-phenylpropane unit with a dioxane moiety. Moreover, compound 1 showed selective cytotoxic activity against HL-60 cells (IC50 = 14.50 μmol·L(-1)). These results provided a basis for future development of these agents as anticancer lead compounds.

Keywords: 9, 10-Dihydrophenanthrene; Cytotoxicity; Erathrins A and B; Eria bambusifolia.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Survival / drug effects*
  • Dendrobium / chemistry*
  • HL-60 Cells
  • Humans
  • Molecular Structure
  • Phenanthrenes / chemistry*
  • Phenanthrenes / pharmacology*
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Phenanthrenes
  • Plant Extracts
  • phenanthrene