A Kinetic Self-Sorting Approach to Heterocircuit [3]Rotaxanes

Edward A Neal; Stephen M Goldup

doi:10.1002/anie.201606640

A Kinetic Self-Sorting Approach to Heterocircuit [3]Rotaxanes

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12488-93. doi: 10.1002/anie.201606640. Epub 2016 Sep 7.

Authors

Edward A Neal¹, Stephen M Goldup²

Affiliations

¹ School of Biological and Chemical Sciences, Queen Mary University of London, UK.
² School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK. s.goldup@soton.ac.uk.

Abstract

In this proof-of-concept study, an active-template coupling is used to demonstrate a novel kinetic self-sorting process. This process iteratively increases the yield of the target heterocircuit [3]rotaxane product at the expense of other threaded species.

Keywords: CuAAC; active templates; cycloaddition; rotaxanes; self-sorting.

Publication types

Research Support, Non-U.S. Gov't