Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease

Eur Respir J. 2016 Oct;48(4):1215-1218. doi: 10.1183/13993003.01125-2016. Epub 2016 Sep 1.

Authors

Jeffrey T J Huang¹, Charlotte E Bolton², Bruce E Miller³, Ruth Tal-Singer³, Roberto A Rabinovich⁴, Colin N A Palmer⁵, Neil C Thomson⁶, William MacNee⁴; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

Affiliations

¹ School of Medicine, University of Dundee, Dundee, UK j.t.j.huang@dundee.ac.uk.
² Nottingham Respiratory Research Unit, School of Medicine, University of Nottingham, Nottingham, UK.
³ Respiratory Therapy Area Unit, GSK, King of Prussia, PA, USA.
⁴ MRC/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.
⁵ School of Medicine, University of Dundee, Dundee, UK.
⁶ Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

PMID: 27587547
DOI: 10.1183/13993003.01125-2016

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age Factors
Aged
Aged, 80 and over
Desmosine / metabolism*
Elastin / metabolism*
Female
Forced Expiratory Volume
Humans
Isodesmosine / metabolism*
Male
Middle Aged
Pulmonary Disease, Chronic Obstructive / metabolism*
Pulmonary Disease, Chronic Obstructive / physiopathology
Smoking / metabolism*
Time Factors

Substances

Desmosine
Elastin
Isodesmosine

Associated data

ClinicalTrials.gov/NCT00292552