The authors compare the dynamics of serum glycoproteins concurrently with monitoring of changes of cellular defence in patients with laryngeal carcinoma, IInd clinical stage. In 20 operated patients with subsequent radiotherapy [group A] better results were achieved as well as normalization of glycoproteins in the course of treatment. The immune response has in the early postoperative period a declining trend. Later in the course of radiotherapy the concentration of IgA and IgM globulins rises with the exception of IgG globulins the concentration of which declined below values of the initial concentrations. The activity of T lymphocytes did not change substantially during treatment, contrary to 19 patients treated by radiotherapy only [group B] where T lymphocytes declined by as much as 14.7%. Also the majority of glycoprotein concentrations remain reduced in group B at the end of the investigation [6 months] with a maximum drop after administration of half the radiation dose [with the exception of alpha 2-macroglobulin and the C3 component of complement]. The IgA and IgG globulin concentrations declined, IgM increased partly. The results correlate with the mortality: in the course of three years in group B 9 patients died, while in group A only three patients which suggests that combined treatment [surgical and radiotherapy] offer better chances of cure.