Erythro-lectin immuno test (Erythro-LIT) in the immunodiagnosis of neurocysticercosis

Braz J Med Biol Res. 1989;22(1):69-75.

Abstract

1. The effectiveness of the Erythro-Lectin Immuno Test (Erythro-LIT) to detect anticysticercus antibodies was tested using cerebrospinal fluid (CFS) from patients with neurocysticercosis. 2. Both Erythro-LIT and complement fixation (CF) were used to detect antibodies in 36 CSF samples from cysticercotic patients. Erythro-LIT detected anticysticercus antibodies in 35 CSF samples (97%) and CF in 26 (72%). The antibody titers ranged from 1:4 to 1:4096 for Erythro-LIT (mean geometric titer = 282.65) and 1:1 to 1:64 in CF (mean geometric titer = 7.92). 3. When greater than or equal to 1:16 Erythro-LIT titer was used as a significant diagnostic cut-off value, the sensitivity and specificity of Erythro-LIT were 92% and 100%, respectively, for CFS. 4. The high sensitivity and specificity demonstrated here, together with the simplicity and low cost of the test, make the Erythro-LIT a potentially useful method for screening for specific antibodies in neurocysticercosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Helminth / cerebrospinal fluid*
  • Central Nervous System Diseases / cerebrospinal fluid*
  • Cysticercosis / cerebrospinal fluid*
  • Cysticercus / immunology*
  • Humans
  • Immunologic Tests / methods*
  • Taenia / immunology*

Substances

  • Antibodies, Helminth