Abstract
A novel fluoroporphyrin-anthraquinone hybrid with dipeptide link and its metal complexes were synthesized and evaluated for anti-proliferation activity in human cancer cell line HeLa. The preliminary results demonstrated that all the compounds showed moderate to excellent antitumor activities. Among the active compounds, compound 3 which contains fluorinated porphyrin-anthraquinone and zinc ion exhibited the highest potency with IC50 value of 8.83 µM, indicating that it was a promising antitumor candidate.
MeSH terms
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Anthraquinones / chemical synthesis
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Anthraquinones / chemistry
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Anthraquinones / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Drug Design*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Molecular Structure
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Porphyrins / chemical synthesis
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Porphyrins / chemistry
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Porphyrins / pharmacology*
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Structure-Activity Relationship
Substances
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Anthraquinones
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Antineoplastic Agents
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Porphyrins