1 aInstitute for Clinical Pharmacology, Hannover Medical School, Hannover, Germany bDivision of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Service, Vanderbilt University, Nashville, Tennessee, USA cDipartimento di Medicina e Chirurgia, Clinica Medica, Universita' Milano-Bicocca; IRCCS Multimedica, Milano, Italy.