Nanoscale Polymer Metal-Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Weiqi Wang; Lei Wang; Yang Li; Shi Liu; Zhigang Xie; Xiabin Jing

doi:10.1002/adma.201602997

Nanoscale Polymer Metal-Organic Framework Hybrids for Effective Photothermal Therapy of Colon Cancers

Adv Mater. 2016 Nov;28(42):9320-9325. doi: 10.1002/adma.201602997. Epub 2016 Aug 30.

Authors

Weiqi Wang^{1

2}, Lei Wang¹, Yang Li^{1

3}, Shi Liu¹, Zhigang Xie¹, Xiabin Jing¹

Affiliations

¹ State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, Jilin, 130022, P. R. China.
² University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
³ College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 060004, P. R. China.

PMID: 27573036
DOI: 10.1002/adma.201602997

Abstract

A UiO-66 core with various sizes acts as heterogeneous nucleation center and enables aniline polymerization under ambient conditions. The as-synthesized UiO-66@PAN possesses uniform size and excellent dispersibility in aqueous solution. UiO-66@PAN can be internalized by cancer cells via endocytosis, and indicates significant photothermal therapeutic effect in vitro, and can effectively inhibit the growth of colon cancers in vivo.

Keywords: metal-organic frameworks; photothermal therapy; polyanilines.

MeSH terms

Colonic Neoplasms / pathology
Colonic Neoplasms / therapy*
Endocytosis
HCT116 Cells
Humans
Hyperthermia, Induced / methods*
Metal-Organic Frameworks / chemistry*
Phototherapy / methods*
Polymers / chemistry*

Substances

Metal-Organic Frameworks
Polymers