Abstract
Proliferation of large granular lymphocytes may be associated with neutropenia and, less frequently, thrombocytopenia. In this report, we describe a patient with severe aplastic anemia in the setting of a proliferation of cells with natural killer (NK) phenotype. We demonstrated evolution to acute lymphoblastic leukemia by cells of identical phenotype.
MeSH terms
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Anemia, Aplastic / blood
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Anemia, Aplastic / immunology*
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Anemia, Aplastic / pathology
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Cell Division
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Humans
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Killer Cells, Natural / pathology*
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Male
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Middle Aged
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Phenotype
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology