Glioma in Patients with Autosomal-Dominant Polycystic Kidney Disease

World Neurosurg. 2017 Feb:98:885.e1-885.e5. doi: 10.1016/j.wneu.2016.08.045. Epub 2016 Aug 24.

Abstract

Background: Autosomal-dominant polycystic kidney disease (ADPKD) is an inherited systemic condition with a predominant feature of cyst formation in both kidneys. An association with intracranial glioma has not been described previously in ADPKD.

Case description: We report 2 cases of glioma in patients with ADPKD. One patient had a cystic lesion with contrast enhancement in the right temporal lobe as revealed by magnetic resonance imaging and an aneurysm in left sylvian fissure confirmed by computed tomography angiography. Subsequent histopathologic analysis of the resected enhancing lesion confirmed the diagnosis of glioblastoma (World Health Organization grade IV). The second patient was found to harbor a solid lesion in the right parietal lobe. This lesion also proved to be an astrocytoma (World Health Organization grade II).

Conclusions: These 2 independent cases of glioma suggest an unusual clinical manifestation of ADPKD. The potential association between ADPKD and glioma pathogenesis should be further explored.

Keywords: Autosomal-dominant polycystic kidney disease; Glioma; Treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Glioma / complications*
  • Glioma / diagnostic imaging
  • Glioma / surgery*
  • Humans
  • Intracranial Aneurysm / complications*
  • Intracranial Aneurysm / diagnostic imaging
  • Intracranial Aneurysm / surgery*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neurosurgical Procedures / methods*
  • Polycystic Kidney, Autosomal Dominant / complications*
  • Polycystic Kidney, Autosomal Dominant / diagnostic imaging
  • Polycystic Kidney, Autosomal Dominant / surgery*
  • Tomography Scanners, X-Ray Computed