A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy

Affiliations

• ¹ State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai 200031, China.
• ² Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
• ³ School of Life Sciences and Biotechnology, Shanghai Jiaotong University, Shanghai, China.
• ⁴ School of Life Science and Technology, Shanghai Tech University, Shanghai 200031, China.
• ⁵ Collaborative Innovation Center for Genetics and Development, Fudan University, Shanghai, China.
• ⁶ Vascular Biology and Therapeutic Program and Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.