Non-Coding RNA Molecules Connect Calorie Restriction and Lifespan

Karan J Abraham; Lauren A Ostrowski; Karim Mekhail

doi:10.1016/j.jmb.2016.08.020

Non-Coding RNA Molecules Connect Calorie Restriction and Lifespan

J Mol Biol. 2017 Oct 27;429(21):3196-3214. doi: 10.1016/j.jmb.2016.08.020. Epub 2016 Aug 22.

Authors

Karan J Abraham¹, Lauren A Ostrowski¹, Karim Mekhail²

Affiliations

¹ Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.
² Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada; Canada Research Chairs Program, Faculty of Medicine, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. Electronic address: karim.mekhail@utoronto.ca.

PMID: 27561708
DOI: 10.1016/j.jmb.2016.08.020

Abstract

Calorie restriction (CR) is a broadly effective environmental intervention that extends life by operating through numerous biological processes. Here, we discuss how non-coding RNA (ncRNA) molecules act as mediators and targets of lifespan-extending CR. We also highlight how these RNA molecules connect CR to its effects on genome stability, cell metabolism, programmed cell death, senescence, cancer, and neurodegeneration. We anticipate that an advanced understanding of the connections between CR and non-coding RNA will provide unique insights into aging mechanisms while pointing to novel approaches aimed at modulating aging and age-related diseases.

Keywords: aging; calorie restriction; human disease; non-coding RNA.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging / genetics*
Animals
Caloric Restriction*
Genomic Instability*
Humans
RNA, Untranslated / genetics*

Substances

RNA, Untranslated

Grants and funding

CIHR/Canada