Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma

Abstract

In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.

Keywords: Fas-associated death domain protein (FADD); T-cell lymphoblastic lymphoma; expression and phosphorylation; prognostic marker; tumor aggressiveness.