Histopathological changes of fibrosis in human extra-ocular muscle caused by botulinum toxin A

Ji Li; Alexandra Allende; Frank Martin; Clare L Fraser

doi:10.1016/j.jaapos.2016.04.009

Histopathological changes of fibrosis in human extra-ocular muscle caused by botulinum toxin A

J AAPOS. 2016 Dec;20(6):544-546. doi: 10.1016/j.jaapos.2016.04.009. Epub 2016 Aug 20.

Authors

Ji Li¹, Alexandra Allende², Frank Martin³, Clare L Fraser⁴

Affiliations

¹ Concord General Repatriation Hospital, Sydney. Electronic address: jili7637@gmail.com.
² Douglass Hanly Moir Pathology, Sydney.
³ Westmead Children's Hospital, Sydney.
⁴ Save Sight Institute, University of Sydney, Sydney.

PMID: 27553530
DOI: 10.1016/j.jaapos.2016.04.009

Abstract

We report the histopathological findings in 3 patients where injections of botulinum toxin were used prior to strabismus surgery. In all cases we found evidence of permanent extraocular muscle atrophy and fibrosis.

MeSH terms

Atrophy
Botulinum Toxins
Botulinum Toxins, Type A / adverse effects*
Humans
Injections, Intramuscular
Oculomotor Muscles / drug effects*
Oculomotor Muscles / pathology
Strabismus / drug therapy*

Substances

Botulinum Toxins
Botulinum Toxins, Type A