Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

Furong Tian; João Conde; Chenchen Bao; Yunsheng Chen; James Curtin; Daxiang Cui

doi:10.1016/j.biomaterials.2016.08.014

Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging

Biomaterials. 2016 Nov:106:87-97. doi: 10.1016/j.biomaterials.2016.08.014. Epub 2016 Aug 12.

Authors

Furong Tian¹, João Conde², Chenchen Bao³, Yunsheng Chen⁴, James Curtin⁵, Daxiang Cui⁴

Affiliations

¹ School of Food Science and Environmental Health, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland. Electronic address: furong.tian@dit.ie.
² Massachusetts Institute of Technology, Institute for Medical Engineering and Science, Harvard-MIT Division for Health Sciences and Technology, Cambridge, MA, USA; School of Engineering and Materials Science, Queen Mary University of London, London, UK. Electronic address: jdconde@mit.edu.
³ Department of Bio-Nano Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; Dept. of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; United Well Technology Limited, Shanghai, PR China.
⁴ Department of Bio-Nano Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China; Dept. of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, PR China.
⁵ School of Food Science and Environmental Health, College of Sciences and Health, Dublin Institute of Technology, Dublin, Ireland.

PMID: 27552319
DOI: 10.1016/j.biomaterials.2016.08.014

Abstract

The application of plasmonic-enhanced Raman imaging of cancer cells and drug delivery is gaining momentum. Here, we propose a new theranostic strategy based on an efficient plasmonic-tunable Raman/Fourier transform infrared (FTIR) spectroscopy imaging, to simultaneously evaluate the anticancer drug scattering cellular imaging and the Raman scattering molecular vibration signals in living cells. This technique allows to monitoring the drug release throughout the cell cycle and in vivo biodistribution and biocompatibility with low dose drug therapy (200 μg/mL) and low toxicity effect. This system can directly track in real-time the delivery and release of an anticancer drug (mitoxantrone, MTX) from gold nanostars in single living cells and in mice (healthy and lung cancer mice models), revealing a strong accumulation in the heart of healthy mice 5 min after administration and infiltration in the tumor site of lung cancer mice 5 h after systemic injection. This in vivo SERS detection method holds a great promise for application in image-guided cancer chemotherapy or as a nonspecific anti-inflammatory therapy for patients with cardiovascular diseases or chronic heart failure.

Keywords: Drug delivery; Gold nanostars; In vivo SERS; Raman/FTIR imaging; Theranostics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / administration & dosage
Antineoplastic Agents / chemistry
Cell Line, Tumor
Computer Systems
Contrast Media / chemistry
Drug Monitoring / methods
Gold / administration & dosage
Gold / chemistry
Metal Nanoparticles / administration & dosage*
Metal Nanoparticles / chemistry
Metal Nanoparticles / ultrastructure
Mice
Molecular Imaging / methods
Nanocapsules / administration & dosage*
Nanocapsules / chemistry
Nanocapsules / ultrastructure
Neoplasms / drug therapy*
Neoplasms / pathology*
Spectroscopy, Fourier Transform Infrared / methods*
Spectrum Analysis, Raman / methods*
Surface Plasmon Resonance / methods*
Theranostic Nanomedicine / methods
Treatment Outcome

Substances

Antineoplastic Agents
Contrast Media
Nanocapsules
Gold