Evidence and Role for Bacterial Mucin Degradation in Cystic Fibrosis Airway Disease

PLoS Pathog. 2016 Aug 22;12(8):e1005846. doi: 10.1371/journal.ppat.1005846. eCollection 2016 Aug.

Abstract

Chronic lung infections in cystic fibrosis (CF) patients are composed of complex microbial communities that incite persistent inflammation and airway damage. Despite the high density of bacteria that colonize the lower airways, nutrient sources that sustain bacterial growth in vivo, and how those nutrients are derived, are not well characterized. In this study, we examined the possibility that mucins serve as an important carbon reservoir for the CF lung microbiota. While Pseudomonas aeruginosa was unable to efficiently utilize mucins in isolation, we found that anaerobic, mucin-fermenting bacteria could stimulate the robust growth of CF pathogens when provided intact mucins as a sole carbon source. 16S rRNA sequencing and enrichment culturing of sputum also identified that mucin-degrading anaerobes are ubiquitous in the airways of CF patients. The collective fermentative metabolism of these mucin-degrading communities in vitro generated amino acids and short chain fatty acids (propionate and acetate) during growth on mucin, and the same metabolites were also found in abundance within expectorated sputum. The significance of these findings was supported by in vivo P. aeruginosa gene expression, which revealed a heightened expression of genes required for the catabolism of propionate. Given that propionate is exclusively derived from bacterial fermentation, these data provide evidence for an important role of mucin fermenting bacteria in the carbon flux of the lower airways. More specifically, microorganisms typically defined as commensals may contribute to airway disease by degrading mucins, in turn providing nutrients for pathogens otherwise unable to efficiently obtain carbon in the lung.

MeSH terms

  • Cystic Fibrosis / metabolism
  • Cystic Fibrosis / microbiology*
  • Female
  • Humans
  • Lung / metabolism
  • Lung / microbiology*
  • Male
  • Mucins / metabolism*
  • Propionates / metabolism*
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / metabolism*
  • RNA, Bacterial / genetics
  • RNA, Ribosomal, 16S / genetics

Substances

  • Mucins
  • Propionates
  • RNA, Bacterial
  • RNA, Ribosomal, 16S