Focal Cortical Dysplasia in Childhood Epilepsy

Tarek Shaker; Anne Bernier; Lionel Carmant

doi:10.1016/j.spen.2016.06.007

Focal Cortical Dysplasia in Childhood Epilepsy

Semin Pediatr Neurol. 2016 May;23(2):108-19. doi: 10.1016/j.spen.2016.06.007. Epub 2016 Jun 15.

Authors

Tarek Shaker¹, Anne Bernier¹, Lionel Carmant²

Affiliations

¹ Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
² Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada. Electronic address: lionel.carmant@umontreal.ca.

PMID: 27544467
DOI: 10.1016/j.spen.2016.06.007

Abstract

Focal cortical dysplasia is a common cause of medication resistant epilepsy. A better understanding of its presentation, pathophysiology and consequences have helped us improved its treatment and outcome. This paper reviews the most recent classification, pathophysiology and imaging findings in clinical research as well as the knowledge gained from studying genetic and lesional animal models of focal cortical dysplasia. This review of this recently gained knowledge will most likely help develop new research models and new therapeutic targets for patients with epilepsy associated with focal cortical dysplasia.

Publication types

Review

MeSH terms

Animals
Child
Disease Models, Animal*
Epilepsy* / etiology
Humans
Malformations of Cortical Development* / complications