Abstract
It is increasingly clear that many metabolic enzymes mistakenly form minor but toxic side-products that must be eliminated to maintain normal fluxes. Collard et al. show that this is true of two iconic glycolytic enzymes, and that a hitherto somewhat mysterious phosphatase rescues central carbon metabolism from their mistakes.
Keywords:
glycolysis; metabolite damage; metabolite repair; phosphatase; side-reaction.
Copyright © 2016 Elsevier Ltd. All rights reserved.
MeSH terms
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Fructosediphosphates / metabolism
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Gluconates / metabolism
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Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / genetics
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Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism*
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Glycolysis / drug effects
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Humans
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Hydrolysis
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Lactates / metabolism
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Lactates / toxicity
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Phosphoric Monoester Hydrolases / antagonists & inhibitors
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Phosphoric Monoester Hydrolases / genetics
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Phosphoric Monoester Hydrolases / metabolism*
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Pyruvate Kinase / genetics
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Pyruvate Kinase / metabolism*
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RNA, Small Interfering / genetics
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RNA, Small Interfering / metabolism
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
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Saccharomyces cerevisiae Proteins / antagonists & inhibitors
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism*
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Secondary Metabolism*
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Sugar Acids / metabolism
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Sugar Acids / toxicity
Substances
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4-phosphoerythronate
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Fructosediphosphates
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Gluconates
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Lactates
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RNA, Small Interfering
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Saccharomyces cerevisiae Proteins
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Sugar Acids
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2-phospholactic acid
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fructose 2,6-diphosphate
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Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
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Pyruvate Kinase
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Pho13 protein, S cerevisiae
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phosphoglycolate phosphatase
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Phosphoric Monoester Hydrolases
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6-phosphogluconic acid