Self-assembling peptide-based building blocks in medical applications

Handan Acar; Samanvaya Srivastava; Eun Ji Chung; Mathew R Schnorenberg; John C Barrett; James L LaBelle; Matthew Tirrell

doi:10.1016/j.addr.2016.08.006

Self-assembling peptide-based building blocks in medical applications

Adv Drug Deliv Rev. 2017 Feb:110-111:65-79. doi: 10.1016/j.addr.2016.08.006. Epub 2016 Aug 14.

Authors

Handan Acar¹, Samanvaya Srivastava², Eun Ji Chung³, Mathew R Schnorenberg⁴, John C Barrett⁵, James L LaBelle⁶, Matthew Tirrell⁷

Affiliations

¹ Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: hacar@uchicago.edu.
² Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL 60439, USA. Electronic address: samsri@uchicago.edu.
³ Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
⁴ Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA; Medical Scientist Training Program, University of Chicago, Chicago, IL 60637, USA. Electronic address: schnorenberg@uchicago.edu.
⁵ Biophysical Sciences Graduate Program, University of Chicago, Chicago, IL 60637, USA. Electronic address: jcbarrett@uchicago.edu.
⁶ Department of Pediatrics, Section of Hematology/Oncology, University of Chicago, Chicago, IL 60637, USA. Electronic address: jlabelle@peds.bsd.uchicago.edu.
⁷ Institute for Molecular Engineering, University of Chicago, Chicago, IL 60637, USA; Institute for Molecular Engineering, Argonne National Laboratory, Argonne, IL 60439, USA. Electronic address: mtirrell@uchicago.edu.

Abstract

Peptides and peptide-conjugates, comprising natural and synthetic building blocks, are an increasingly popular class of biomaterials. Self-assembled nanostructures based on peptides and peptide-conjugates offer advantages such as precise selectivity and multifunctionality that can address challenges and limitations in the clinic. In this review article, we discuss recent developments in the design and self-assembly of various nanomaterials based on peptides and peptide-conjugates for medical applications, and categorize them into two themes based on the driving forces of molecular self-assembly. First, we present the self-assembled nanostructures driven by the supramolecular interactions between the peptides, with or without the presence of conjugates. The studies where nanoassembly is driven by the interactions between the conjugates of peptide-conjugates are then presented. Particular emphasis is given to in vivo studies focusing on therapeutics, diagnostics, immune modulation and regenerative medicine. Finally, challenges and future perspectives are presented.

Keywords: Medicine; Peptide; Peptide-conjugates; Self-assembly; Supramolecular.

Publication types

Review

MeSH terms

Animals
Biocompatible Materials / chemical synthesis
Biocompatible Materials / chemistry
Biocompatible Materials / therapeutic use
Drug Design
Humans
Nanostructures / chemistry
Peptides / chemical synthesis
Peptides / chemistry*
Peptides / immunology
Peptides / therapeutic use*
Regenerative Medicine

Substances

Biocompatible Materials
Peptides

Abstract

Publication types

MeSH terms

Substances

Grants and funding