Plant Resources, (13)C-NMR Spectral Characteristic and Pharmacological Activities of Dammarane-Type Triterpenoids

Molecules. 2016 Aug 12;21(8):1047. doi: 10.3390/molecules21081047.

Abstract

Dammarane-type triterpenoids (DTT) widely distribute in various medicinal plants. They have generated a great amount of interest in the field of new drug research and development. Generally, DTT are the main bioactive ingredients abundant in Araliaceae plants, such as Panax ginseng, P. japonicas, P. notoginseng, and P. quinquefolium. Aside from Araliaceae, DTT also distribute in other families, including Betulaceae, Cucurbitaceae, Meliaceae, Rhamnaceae, and Scrophulariaceae. Until now, about 136 species belonging to 46 families have been reported to contain DTT. In this article, the genus classifications of plant sources of the botanicals that contain DTT are reviewed, with particular focus on the NMR spectral features and pharmacological activities based on literature reports, which may be benefit for the development of new drugs or food additives.

Keywords: Dammarane-type triterpenoids; NMR spectral characteristics; biological activities; plant resources.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry
  • Anti-Inflammatory Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Carbon-13 Magnetic Resonance Spectroscopy*
  • Cell Line, Tumor
  • Humans
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology
  • Macrophages, Peritoneal / drug effects
  • Macrophages, Peritoneal / immunology
  • Macrophages, Peritoneal / metabolism
  • Mice
  • Molecular Structure
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • Plants, Medicinal / chemistry
  • Triterpenes / chemistry*
  • Triterpenes / pharmacology*

Substances

  • Anti-Inflammatory Agents
  • Antineoplastic Agents
  • Immunologic Factors
  • Plant Extracts
  • Triterpenes