Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins

Biochem Soc Trans. 2016 Aug 15;44(4):1058-65. doi: 10.1042/BST20160080.

Abstract

Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands.

Keywords: Matrin3; PTB; RNA; alternative splicing; heterogeneous nuclear ribonucleoprotein (hnRNP); polypyrimidine tract binding protein.

Publication types

  • Review

MeSH terms

  • Binding Sites / genetics
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Heterogeneous-Nuclear Ribonucleoproteins / genetics*
  • Heterogeneous-Nuclear Ribonucleoproteins / metabolism
  • Humans
  • Ligands
  • Models, Genetic
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism
  • Peptides / genetics
  • Peptides / metabolism
  • Polypyrimidine Tract-Binding Protein / genetics*
  • Polypyrimidine Tract-Binding Protein / metabolism
  • RNA Precursors / genetics*
  • RNA Precursors / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / metabolism
  • Ribonucleoproteins

Substances

  • Carrier Proteins
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Ligands
  • Nuclear Proteins
  • PTBP1 protein, human
  • Peptides
  • RAVER1 protein, human
  • RNA Precursors
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • Polypyrimidine Tract-Binding Protein