Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI

Ryan L Brunsing; Natalie M Schenker-Ahmed; Nathan S White; J Kellogg Parsons; Christopher Kane; Joshua Kuperman; Hauke Bartsch; Andrew Karim Kader; Rebecca Rakow-Penner; Tyler M Seibert; Daniel Margolis; Steven S Raman; Carrie R McDonald; Nikdokht Farid; Santosh Kesari; Donna Hansel; Ahmed Shabaik; Anders M Dale; David S Karow

doi:10.1002/jmri.25419

Restriction spectrum imaging: An evolving imaging biomarker in prostate MRI

J Magn Reson Imaging. 2017 Feb;45(2):323-336. doi: 10.1002/jmri.25419. Epub 2016 Aug 16.

Authors

Ryan L Brunsing¹, Natalie M Schenker-Ahmed¹, Nathan S White¹, J Kellogg Parsons², Christopher Kane², Joshua Kuperman¹, Hauke Bartsch¹, Andrew Karim Kader², Rebecca Rakow-Penner¹, Tyler M Seibert³, Daniel Margolis⁴, Steven S Raman⁴, Carrie R McDonald⁵, Nikdokht Farid¹, Santosh Kesari⁶, Donna Hansel⁷, Ahmed Shabaik⁷, Anders M Dale^{1

8}, David S Karow¹

Affiliations

¹ Department of Radiology, University of California San Diego, San Diego, California, USA.
² Department of Surgery, University of California San Diego, San Diego, California, USA.
³ Department of Radiation Medicine, University of California San Diego, San Diego, California, USA.
⁴ Department of Radiology, University of California Los Angeles, Los Angeles, California, USA.
⁵ Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
⁶ Department of Translational Neuro-Oncology and Neurotherapeutics, Pacific Neuroscience Institute and John Wayne Cancer Institute at Providence Saint John's Health Center, Los Angeles, California, USA.
⁷ Department of Pathology, University of California San Diego, San Diego, California, USA.
⁸ Department of Neurosciences, University of California San Diego, La Jolla, California, USA.

Abstract

Restriction spectrum imaging (RSI) is a novel diffusion-weighted MRI technique that uses the mathematically distinct behavior of water diffusion in separable microscopic tissue compartments to highlight key aspects of the tissue microarchitecture with high conspicuity. RSI can be acquired in less than 5 min on modern scanners using a surface coil. Multiple field gradients and high b-values in combination with postprocessing techniques allow the simultaneous resolution of length-scale and geometric information, as well as compartmental and nuclear volume fraction filtering. RSI also uses a distortion correction technique and can thus be fused to high resolution T2-weighted images for detailed localization, which improves delineation of disease extension into critical anatomic structures. In this review, we discuss the acquisition, postprocessing, and interpretation of RSI for prostate MRI. We also summarize existing data demonstrating the applicability of RSI for prostate cancer detection, in vivo characterization, localization, and targeting.

Level of evidence: 5 J. Magn. Reson. Imaging 2017;45:323-336.

Keywords: biomarker; diffusion-weighted imaging; prostate cancer; restriction spectrum imaging.

Publication types

Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Body Water / diagnostic imaging*
Diffusion Magnetic Resonance Imaging / methods*
Evidence-Based Medicine
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Male
Prostatic Neoplasms / diagnostic imaging*
Prostatic Neoplasms / pathology*
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted

Abstract

Publication types

MeSH terms

Grants and funding