Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance

Miaoxin Chen; Bo Liu; David Wilkinson; Amy T Hutchison; Campbell H Thompson; Gary A Wittert; Leonie K Heilbronn

doi:10.1016/j.orcp.2016.07.004

Selenoprotein P is elevated in individuals with obesity, but is not independently associated with insulin resistance

Obes Res Clin Pract. 2017 Mar-Apr;11(2):227-232. doi: 10.1016/j.orcp.2016.07.004. Epub 2016 Aug 11.

Authors

Miaoxin Chen¹, Bo Liu², David Wilkinson³, Amy T Hutchison², Campbell H Thompson², Gary A Wittert², Leonie K Heilbronn⁴

Affiliations

¹ Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, China; Discipline of Medicine, University of Adelaide, Australia; Research Centre for Reproductive Health, Robinson Research Institute, University of Adelaide, Australia.
² Discipline of Medicine, University of Adelaide, Australia.
³ Discipline of Medicine, University of Adelaide, Australia; Discipline of Acute Care Medicine, University of Adelaide, Australia.
⁴ Discipline of Medicine, University of Adelaide, Australia; Research Centre for Reproductive Health, Robinson Research Institute, University of Adelaide, Australia. Electronic address: leonie.heilbronn@adelaide.edu.au.

PMID: 27524654
DOI: 10.1016/j.orcp.2016.07.004

Abstract

Selenoprotein P (SeP) is secreted primarily by the liver and postulated to cause insulin resistance. The aim of this study was to measure plasma SeP in individuals who are lean (N=29) or overweight/obese (N=34), and examine relationships between circulating SeP, SEPP1 (SeP, plasma 1) expression in subcutaneous adipose tissue, and markers of insulin resistance. SeP was higher in individuals who were overweight/obese (P<0.001), and associated with insulin resistance by HOMA-IR and by clamp, but not independently of BMI. SEPP1 mRNA was correlated negatively with BMI, suggesting there may be tissue specific regulation. This study suggests that obesity, rather than insulin resistance, is central to the increase in SeP.

Trial registration: ClinicalTrials.gov NCT01230632 NCT02009813 NCT01769976.

Keywords: Insulin resistance; Obesity; Selenoprotein P.

MeSH terms

Adolescent
Adult
Blood Glucose
Child
Cholesterol / blood
Female
Humans
Insulin Resistance / physiology*
Male
Middle Aged
Obesity / blood*
Overweight / blood*
Selenoprotein P / blood*
Young Adult

Substances

Blood Glucose
Selenoprotein P
Cholesterol

Associated data

ClinicalTrials.gov/NCT01230632
ClinicalTrials.gov/NCT02009813
ClinicalTrials.gov/NCT01769976