Peptide-based biocoatings for corrosion protection of stainless steel biomaterial in a chloride solution

Noah G G Muruve; Y Frank Cheng; Yuanchao Feng; Tao Liu; Daniel A Muruve; Daniel J Hassett; Randall T Irvin

doi:10.1016/j.msec.2016.06.053

Peptide-based biocoatings for corrosion protection of stainless steel biomaterial in a chloride solution

Mater Sci Eng C Mater Biol Appl. 2016 Nov 1:68:695-700. doi: 10.1016/j.msec.2016.06.053. Epub 2016 Jun 16.

Authors

Noah G G Muruve¹, Y Frank Cheng², Yuanchao Feng³, Tao Liu³, Daniel A Muruve⁴, Daniel J Hassett⁵, Randall T Irvin⁶

Affiliations

¹ Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada; Department of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
² Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada. Electronic address: fcheng@ucalgary.ca.
³ Department of Mechanical & Manufacturing Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.
⁴ Department of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.
⁵ Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA.
⁶ Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, AB T6G 2G6, Canada.

PMID: 27524070
DOI: 10.1016/j.msec.2016.06.053

Abstract

In this work, PEGylated D-amino acid K122-4 peptide (D-K122-4-PEG), derived from the type IV pilin of Pseudomonas aeruginosa, coated on 304 stainless steel was investigated for its corrosion resistant properties in a sodium chloride solution by various electrochemical measurements, surface characterization and molecular dynamics simulation. As a comparison, stainless steel electrodes coated with non-PEGylated D-amino acid retroinverso peptide (RI-K122-4) and D-amino acid K122-4 peptide (D-K122-4) were used as control variables during electrochemical tests. It was found that the D-K122-4-PEG coating is able to protect the stainless steel from corrosion in the solution. The RI-K122-4 coating shows corrosion resistant property and should be investigated further, while the D-K122-4 peptide coating, in contrast, shows little to no effect on corrosion. The morphological characterizations support the corrosion resistance of D-K122-4-PEG on stainless steel. The adsorption of D-K122-4 molecules occurs preferentially on Fe2O3, rather than Cr2O3, present on the stainless steel surface.

Keywords: Biocoatings; Corrosion protection; Electrochemical measurements; Molecular dynamics simulation; Peptides; Stainless steel.

MeSH terms

Chromium Compounds / chemistry
Coated Materials, Biocompatible / chemistry*
Corrosion
Ferric Compounds / chemistry
Fimbriae Proteins / chemistry*
Peptides / chemistry*
Pseudomonas aeruginosa / chemistry*
Stainless Steel / chemistry*

Substances

Chromium Compounds
Coated Materials, Biocompatible
Ferric Compounds
Peptides
Stainless Steel
Fimbriae Proteins
ferric oxide