Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Simranpreet Kaur; Liza Jane Raggatt; Lena Batoon; David Arthur Hume; Jean-Pierre Levesque; Allison Robyn Pettit

doi:10.1016/j.semcdb.2016.08.009

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Semin Cell Dev Biol. 2017 Jan:61:12-21. doi: 10.1016/j.semcdb.2016.08.009. Epub 2016 Aug 10.

Authors

Simranpreet Kaur¹, Liza Jane Raggatt², Lena Batoon³, David Arthur Hume⁴, Jean-Pierre Levesque⁵, Allison Robyn Pettit⁶

Affiliations

¹ Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: simranpreet.Kaur@mater.uq.edu.au.
² Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: liza-jane.raggatt@mater.uq.edu.au.
³ Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: lena.batoon@mater.uq.edu.au.
⁴ The Roslin Institute and Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Roslin, Midlothian EH25 9PS, Scotland, United Kingdom. Electronic address: david.hume@roslin.ed.ac.uk.
⁵ Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: jp.levesque@mater.uq.edu.au.
⁶ Blood and Bone Diseases Program, Mater Research Institute - The University of Queensland, Faculty of Medicine and Biomedical Sciences, Translational Research Institute, 37 Kent Street, Woolloongabba, 4102, Australia. Electronic address: allison.pettit@mater.uq.edu.au.

PMID: 27521519
DOI: 10.1016/j.semcdb.2016.08.009

Abstract

Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected tissues. Three subsets of bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.

Keywords: Bone and bone marrow; Haematopoiesis; Macrophages; Stem cell niches.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Bone Marrow / pathology*
Bone and Bones / pathology*
Homeostasis*
Humans
Macrophages / pathology*
Stem Cell Niche*
Wound Healing*